GPCR Workshop Agenda Dec 5 — 9 , 2017, Big Island of Hawaii

Preliminary Program - Sessions and Topics:

Day 1 Tuesday, December 5th
14:00 - 16:00 Registration
16:00 - 16:10 Welcome Brian Kobilka, Chair, Stanford University, USA
16:10 - 17:10 Keynote Speaker Klaus Peter Hofmann. Charité - Universitätsmedizin Berlin
17:30 - 18:30 Poster Preview Presentations Katie Leach, Chair Monash Institute of Pharaceutical Sciences
18:30 Welcome Reception  

Day 2 Wednesday, December 6th
Session 2 Structure 1 Chair: Sebastian Granier
8:30 - 9:10 Structural Mechanisms of Ligand-dependent Activation in Class C GPCRs Qing Fan, Columbia University
9:10 - 9:50 Structural Insights into Family B GPCR Activation Patrick Sexton, Monash Institute of Pharaceutical Sciences
9:50 - 10:30 Structural and Functional Analysis of a GPCR-GRK Complex Jeff Benovic, Thomas Jefferson University, Pittsburgh
10:30 - 11:00 Break
Session 3 Chemical Biology Chair: Arthur Christopoulos
11:00 - 11:40 Novel Selective Ligands Based on GPCR Crystal Structures Peter Gmeiner, University of Erlangen-Nurnberg, Germany
11:40 - 12:20 Structure-based Screening for GPCR Ligands from Fragment and Lead-like Chemical Space Jens Carlsson, Uppsala  University, Sweden
12:20 - 13:00 From Chemokine Receptors to Orphan GPCRs: In Silico Insights into Ligand Interactions Irina Kufareva, UCSD
13:00 - 15:30 Lunch and Poster Viewing
15:30 - 19:30 Free Time and Preparation for Interactive Discussion Session
19:30 - 21:30 Interactive Discussion Chair: Roger Sunahara

Day 3 Thursday, December 7th
Session 4 Structure 2 Chair: Brian Kobilka
8:30 - 9:00 Structural Insights into G Protein Activation Xiang Yu Liu, Tsinghua University, Beijing
9:00 - 9:40 Structure and Function of Adiponectin Receptors Sebastian Granier, Institut de Génomique Fonctionnelle, Montpellier, France
9:40 - 10:20 Structural and Functional Basis of Adhesion GPCR Activation Demet Arac, University of Chicago
10:20 - 10:30 Break  
Session 5 Physiology Chair: Martin Lohse
10:30 - 11:10 Regulation of Cardiovascular Functions in Health and Disease by GPCRs Stefan Offermanns, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
11:10 - 11:50 Biological Functions of GPCRs and Beta-arrestins Studied with Novel Mutant Mouse Models Jurgen Wess, NIH
11:50 - 12:30 Fine-tuning Calcium Sensing Receptor Activity to Treat Bone and Mineral Disorders Katie Leach, Monash Institute of Pharaceutical Sciences
12:30 - 13:10 From Cognition to Seizures: Novel Molecular Mechanisms Underlying Key Muscarinic Receptor Action Andrew Tobin, University of Leicester, UK
13:10 - 15:30 Lunch and Poster Viewing  
15:30 - 19:30 Free Time and Preparation for Interactive Discussion Session
19:30 - 21:30 Interactive Discussion Chair: Andrew Tobin
18:00 Sunset Dinner/Banquet

Day 4 Friday, December 8th
Session 6 GPCRs in the Clinic Chair: Stefan Offermanns
8:30 - 9:10 Novel GPCR Targets for Obesity and Type 2 Diabetes Treatment Lora Heisler, University of Aberdeen, NZ
9:10 - 9:50 GPCR Ligands in the Novo Nordisk Diabetes and Obesity Pipeline Lotte Bjerre Knudsen, Novo Nordisk, Denmark
9:50 - 10:30 GPCR Directed Biologics – From Discovery Strategies to the Clinic Andrew Tebben, Bristol Myers Squibb
10:30 - 11:00 Break
Session 7 Signaling Chair: Jurgen Wess
11:00 - 11:40 Progress Toward Understanding GPCR Signaling From Endosomes Mark von Zastrow, UCSF
11:40 - 12:20 TBA Stefan Offermanns, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
12:20 - 13:00 Toward a Structural Understanding of Ligand-biased Signalling Michel Bouvier, University of Montreal, Canada
13:00 - 14:30 Lunch and poster take down  
14:30 - 15:30 Free Time and Preparation for Interactive Discussion Session
15:30 - 17:30 Interactive Session Chair: Mark von Zastrow

Day 5 Saturday, December 9th
Session 8 Potpourri Chair: Patrick Sexton
9:30 - 10:10 Allostery in G Protein-coupled Receptors: Rrom G Proteins to Small Molecules to Cations. Roger Sunahara, UCSD
10:10 - 10:50 Machine Learning and Visualization for GPCR-ligand Interaction Analysis A.J. Venkatakrishnan and Rasmus Fonseca, Stanford
10:50 - 11:40 TBD Martin Lohse
11:40 - 12:00 Closing Remarks by Organizers - Lunch Arthur, Patrick, Tong Sun


Chat Board for Attendees

If you want to coordinate transportation, discuss room sharing or other topics for the seminar, please visit the chat board we have set up for our attendees, GPCR Workshop Chat Board