AGENDA

GPCR Workshop Program Sessions & Topics

15 min Short Talk (10 min presentation + 5 min FAQ), Presenters selected from abstract submissions.
40 min Regular Talk (30 min presentation + 10 min FAQ).

Download printable version (pdf)

Day 1: Dec. 12, 2025

8:00am - 9:00am

Breakfast

9:00am - 12:00pm

Brian’s Birthday Session (alumni + friends)
12:00pm - 1:00pm
Lunch
2:00pm - 4:00pm

REGISTRATION

Session 1

Chair: Brian Kobilka
Stanford University

4:00pm - 4:05pm
Welcome: Brian Kobilka

Brian Kobilka
Stanford University

4:05pm - 4:45pm

Receptor-stimulated G12 signaling regulates key metabolic functions

Jürgen Wess
NIDDK, NIH

4:45pm - 5:25pm
Uncovering unconventional GPCR stimuli

Aashish Manglik
UCSF

5:25pm - 6:05pm
Translational mechanisms for GPR75 loss-of-function driving protection from obesity

Judith Altarejos
Regeneron Pharmaceuticals

6:05pm - 6:35pm

Kidney Exchange

Alvin Roth
Stanford University

6:35pm - onward
Reception

Day 2: Dec. 13, 2025

7:30am - 8:20am

Breakfast

Session 2

Chair: Brian Kobilka
Stanford University

8:20am - 9:10am
Higher Order Transient Structures and the Principle of Dynamic Connectivity in Membrane Signaling

Rod MacKinnon
The Rockefeller University

9:10am - 9:50am
Exploring the Subcellular Organization of GPCR Signaling

Mark von Zastrow
UCSF

9:50am - 10:05am

SHORT TALK #1
Identifying the role of the extracellular vestibule in ligand-dependent b2-adrenergic receptor endocytosis

Nicole McIntosh
University of California, San Diego

10:05am - 10:25am
Break
10:25am - 11:05am
Arrestin binding to GPCRs lacking the C-tail

Irene Coin
Leipzig University

11:05am - 11:45am
A structural view of MC4R signaling induced by ligands and genetic variants relevant to body weight regulation

Patrick Scheerer
 Charité Universitätsmedizin Berlin

11:45am - 12:25pm
 Computational reprogramming of GPCR signal transduction

Patrick Barth
Ecole Polytechnique Fédérale de Lausanne

12:25pm - 12:40pm

SHORT TALK #2
Compartmentalised autonomic signalling reveals distinct sympathetic and parasympathetic domains in cardiac myocytes

Alexander Demby
University of Oxford

12:40pm - 3:00pm
 Lunch and Poster Viewing

Session 3

Chair: Jürgen Wes
NIDDK, NIH

3:00pm - 3:40pm
Structure and function of non-canonical GPCR signaling complexes

Kirill Martemyanov
University of Florida

3:40pm - 4:20pm
Mechanistic insights into G-protein coupling with an agonist-bound GPCR: implications for coupling specificity

Peter Hildebrand
Leipzig University

4:20pm - 5:00pm
A new type of biosensor to dissect GPCR conformational equilibria in intact cells

Andreas Bock
University Medical Center Mainz

5:00pm - 5:15pm

SHORT TALK #3
Structural basis of a stepwise Gq activation by a chemokine receptor US28

Naotaka Tsutsumi
Institute of Science Tokyo

5:15pm - 5:30pm

SHORT TALK #4
Fluorogenic-Based Biosensors Reveal Specific and Universal Regulators of Endosomal GPCRs

Braden Lobinger
Oregon Health Sciences University

5:30pm - 6:30pm
Poster Session
6:30pm - 8:00pm
Dinner
8:00pm - 10:00pm
INTERACTIVE SESSION #1

Roger Sunahara
UCSD

Day 3: Dec. 14, 2025

7:30am - 8:30am

Breakfast

Session 4

Chair: Aashish Manglik
UCSF

8:30am - 9:10am
Leveraging Computational and Experimental Data to Advance Knowledge of GPCR Signaling and Drug Discovery

Marta Filizola
Icahn School of Medicine
at Mount Sinai

9:10am - 9:25am

SHORT TALK #5
The mechanisms of PLC3 activation by Gq and G

Nevin Lambert
Medical College of Georgia, Augusta University

9:25am - 10:05am
New insights into the spatiotemporal organisation of GPCR signalling

Davide Calebiro
University of Birmingham

10:05am - 10:25am
Break
10:25am - 11:05am
How to transduce force into biochemical commands – Mechanosensing by adhesion GPCRs

Tobias Langenhan
Leipzig University

11:05am - 11:45am
Structure and function of GPCR-toxin complexes

Sébastien Granier
Institut de Génomique Fonctionnelle, CNRS/INSERM/Université de Montpellier

11:45am - 12:00pm

SHORT TALK #6
Positive allosteric modulation of CCK1R through the third intracellular loop

Fredrick Sadler
University of Minnesota

12:00pm - 12:30pm
Targeting a cryptic pocket in cannabinoid receptors drives peripheral and functional selectivity

Susruta Majumdar
Washinton University St. Louis

12:30pm - 12:45pm

SHORT TALK #7
Ligand-dependent activation trajectories dictate GPCR signaling efficacy in intact cells

Romy Thomas
 Leipzig University

12:45pm - 3:00PM

Lunch and Poster Viewing

Session 5

Chair: Sebastien Granier
Institut de Génomique Fonctionnelle, CNRS/INSERM/Université de Montpellie

3:00pm - 3:40pm
Unconventional GPCR Signaling in the Hedgehog Pathway and Beyond

Ben Myers
Huntsman Cancer Institute, University of Utah

3:40pm - 4:20pm
Exploring non-canonical signaling mechanisms across diverse GPCRs

Ruth Huttenhain
Stanford University

4:20pm - 5:00pm
Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function

Demet Arac
University of Chicago

5:00pm - 5:15pm

SHORT TALK #8
Unnatural Amino Acid Labeling and smFRET Reveal Intermediate States in Glucagon Receptor Signaling

Shi Feng
Stanford University

5:15pm - 5:30pm
SHORT TALK #9
Single G Protein Turnover Defines DRD2's Coupling Efficiency

Desye Ambaw
The University of Queensland

5:30pm - 6:30pm
Poster Session
6:30pm - 8:00pm
Dinner
8:00pm - 10:00pm

Interactive Session #2

Nevin and Sivaraj

Day 4: Dec. 15, 2025

7:30am - 8:30am

Breakfast

Session 6

Chair: Mark von Zastrow
UCSF

8:30am - 9:10am
Exploring Intracellular GPCRs and Their Role in Pathway Crosstalk

Nina Tsvetanova
Duke University

9:10am - 9:25am

SHORT TALK #10
Age-dependent GPCR expression dynamics guides precision medicine for fetal, pediatric, and geriatric populations

Katarina Nemec
St. Jude Children’s Research Hospital

9:25am - 10:05am
A Survival Pressure Selection method for GPCR drug screening

Xiangyu Liu
Tsinghua University

10:05am - 10:25am
Break
10:25am - 11:05am
Using nanobodies as tools to interrogate and control GPCR signaling

Andrew Kruse
Harvard Medical School

11:05am - 11:45am
Assembly required – how cells build functional ion channel complexes

Tino Pleiner
Stanford University

11:45am - 12:00pm
SHORT TALK #11

tbd

12:00pm - 12:30pm
Multimodal β-arrestin functions through membrane nanodomain formation
Asuka Inoue
Kyoto University
12:30pm - 3:00pm
Lunch and Poster Viewing (Poster takedown at end of this session)

Session 7

Chair: Aashish Manglik
UCSF

3:00pm - 3:40pm
Application of genetically encoded dopamine and 2nd messenger sensors challenge paradigms of dopamine receptor signaling in the striatum

Ulrik Gether
University of Copenhagen

3:40pm - 4:20pm
The role of protein dynamics in GPCR signaling / Closing Remarks

Brian Kobilka
Stanford University

4:20pm - 5:00pm
Conference Discussion / Closeout
6:00pm - 10:00pm

Banquet Dinner