AGENDA

GPCR Workshop Program Sessions & Topics

15 min Short Talk. Presenters to be selected from abstract submissions.

Download printable version (pdf)

Day 1: Dec. 12, 2025

8:00am  - 9:00am

Breakfast (included)

9:00am - 12:00pm

Brian’s Birthday Session (alumni + anyone who wants to hang out)
12:00pm - 1:00pm
Lunch
2:00pm - 4:00pm

REGISTRATION

Session 1

Chair: Brian Kobilka
Stanford University

4:00pm - 4:05pm
Welcome: Brian Kobilka

Brian Kobilka
Stanford University

4:05pm - 4:45pm

Receptor-stimulated G12 signaling regulates key metabolic functions

Jürgen Wess
SNIDDK, NIH

4:45pm -5:25pm

Uncovering unconventional GPCR stimuli

Aashish Manglik
UCFS

5:25pm-6:05pm
Translational mechanisms for GPR75 loss-of-function driving protection from obesity

Judith Altarejos
Regeneron Pharmaceuticals

6:05pm - onward
Reception

Day 2: Dec. 13, 2025

7:30am  - 8:20am

Breakfast (included)

Session 2

Chair: Brian Kobilka
Stanford University

8:20am – 9:10am
Higher Order Transient Structures and the Principle of Dynamic Connectivity in Membrane Signaling

Rod MacKinnon
The Rockefeller University

9:10am – 9:50am
Exploring the Subcellular Organization of GPCR Signaling

Mark von Zastrow
UCSF

9:50am  – 10:05am
SHORT TALK #1
tbd
10:05am – 10:25am
Break
10:25am - 11:05am
Arrestin binding to GPCRs lacking the C-tail

Irene Coin
Leipzig University

11:05am - 11:45am
A structural view of MC4R signaling induced by ligands and genetic variants relevant to body weight regulation

Patrick Scherrer
Charité – Universitätsmedizin Berlin

11:45am - 12:00pm
SHORT TALK #2
tbd
12:00pm - 3:00pm
Lunch / Time Off / Posters

Session 3

Chair: Jürgen Wes
SNIDDK, NIH

3:00pm - 3:40pm
Structure and function of non-canonical GPCR signaling complexes

Kirill Martemyanov
University of Florida

3:40pm - 4:20pm
Mechanistic insights into G-protein coupling with an agonist-bound GPCR: implications for coupling specificity

Peter Hildebrand
Leipzig University

4:20pm - 5:00pm
A new type of biosensor to dissect GPCR conformational equilibria in intact cells

Andreas Bock
Leipzig University

5:00pm - 6:00pm
Poster Session
6:00pm - 8:00 pm
Dinner
8:00pm - 10:00 pm
INTERACTIVE SESSION #1

Rod MacKinnon
The Rockefeller University

Day 3: Dec. 14, 2025

7:30 - 8:30 am

Breakfast (included)

Session 4

Chair: Aashish Manglik
UCFS

8:30am - 9:10am
Leveraging Computational and Experimental Data to Advance Knowledge of GPCR Signaling and Drug Discovery

Marta Filizola
Icahn School of Medicine
at Mount Sinai

9:10am - 9:25am
SHORT TALK #1
9:25am - 10:05am
New insights into the spatiotemporal organisation of GPCR signalling

Davide Calebiro
University of Birmingham

10:05am - 10:25am
Break
10:25am - 11:05am
How to transduce force into biochemical commands – Mechanosensing by adhesion GPCRs

Tobias Langenhan
Leipzig University

11:05am - 11:45am
Structure and function of GPCR-toxin complexes

Sébastien Granier
Institut de Génomique Fonctionnelle, CNRS/INSERM/Université de Montpellier

11:45am - 12:00pm
SHORT TALK #2

tbd

12:00PM - 3:00 pm
Lunch / Time Off / Posters

Session 5

Chair: tbd
tbd

3:00pm - 3:40pm
Unconventional GPCR Signaling in the Hedgehog Pathway and Beyond

Ben Myers
Huntsman Cancer Institute, University of Utah

3:40pm - 4:20pm
Exploring non-canonical signaling mechanisms across diverse GPCRs

Ruth Huttenhain
Stanford University

4:20pm - 5:00 pm
Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function

Demet Arac
University of Chicago

5:0pm - 6:00pm
Poster Session
6:00pm - 8:00pm
Dinner
8:00pm - 10:00pm

Interactive Session #2

Mark von Zastrow
UCSF

Day 4: Dec. 15, 2025

7:30am - 8:30am

Breakfast (included)

Session 6

Chair: Mark von Zastrow
UCFS

8:30am – 9:10am
Exploring Intracellular GPCRs and Their Role in Pathway Crosstalk

Nina Tsvetanova
Duke University

9:10am - 9:25am
SHORT TALK #1
tbd
9:25am- 10:05am
A Survival Pressure Selection method for GPCR drug screening

Xiangyu Liu
Tsinghua University

10:05am - 10:25am
Break
10:25am - 11:05am
Using nanobodies as tools to interrogate and control GPCR signaling

Andrew Kruse
Harvard Medical School

11:05am - 11:45am
Assembly required – how cells build functional ion channel complexes

Tino Pleiner
Stanford University

11:45am - 12:00pm
Short Talk #2

tbd

12:00pm - 3:00pm
Lunch / Time Off / Posters (Poster takedown at end of this session)

Session 7

Chair: Aashish Manglik
UCFS

3:00pm - 3:40pm
Application of genetically encoded dopamine and 2nd messenger sensors challenge paradigms of dopamine receptor signaling in the striatum

Ulrik Gether
University of Copenhagen

3:40pm - 4:20pm
Title TBA / Closing Remarks

Brian Kobilka
Stanford University

4:20pm - 5:00pm
Conference Discussion / Closeout
6:00pm - 10:00pm

Banquet Dinner