AGENDA Jan 3-6, 2023

GPCR Workshop Program Sessions & Topics

20 min Short Talk. Presenters to be selected from abstract submissions.

Download printable version (pdf)

DAY 1 January 3, 2023

2:00 - 4:00 pm

REGISTRATION

Foyer of Kamakahonu Ballroom
SESSION 1
4:00 - 4:20 pm
Opening remarks

Brian Kobilka
Stanford University, CA, USA

4:20 - 5:00 pm
Non-canonical activation of β-arrestin and G protein

Asuka Inoue
Tohoku University, Japan

5:00 - 5:40 pm
Receptor signaling at the nanometer scale

Martin Lohse
SAR Bioscience Institute Munich/ University of Wuerzburg

6:00 - 9:00 pm
RECEPTION

Day 2 January 4, 2023

7:30 - 8:30 am

Breakfast (provided)

Foyer of ballroom
SESSION 2 - Chair Brian Kobilka
8:30 - 9:10 am
Chemogenetic approaches to identify targets for novel antidiabetic drugs

Jurgen Wess
NIH

9:10 - 9:50 am
Illuminating endogenous G proteins with CRISPR

Nevin Lambert
Augusta University

9:50 - 10:30 am
Letting the little light of mind shine with genetically encoded indicators based on GPCRs

Lin Tian
UC Davis

10:30 - 11:10 am
Leveraging novel GPCR signaling cascades in fat tissue to counteract metabolic disease.

Zachary Gerhart-Hines
University of Copenhagen

11:10 - 11:30 am
Break
11:30 - 11:50 am
Short Talk - Investigation of G-protein specificity and biased agonism at the beta-2 adrenergic receptor (β2AR)

Marina Casiraghi
Stanford University

11:50 - 12:10 pm
Short Talk - RXFP2 Small Molecule Agonists: Potential Therapeutics for Osteoporosis

Alexander Agoulnik
Florida International University

12:10 - 3:00 pm
Lunch (on your own) and poster viewing
SESSION 3  - Chair Mark von Zastrow
3:00 - 3:40 pm
GPCR-mediated B-arrestin activation deconvoluted with single-molecule precision

Jonathan Javitch
Columbia University

3:40 - 4:20 pm
Autoregulation of GPCR signaling through the third intracellular loop

Sivaraj Sivaramakrishnan
Univ of MN

4:20 - 5:00 pm
Development of selective ligands for Class A GPCRs: functional selectivity and location-specific activity

Peter Gmeiner
Friedrich Alexander University Erlangen-Nürnberg

5:00 - 6:00 pm
Poster viewing

tbd
tbd

6:00 - 8:00 pm
Dinner  (provided)

location
tbd

8:00 - 10:00 pm
INTERACTIVE SESSION 1

Chair Roger Sunahara
UC San Diego

Day 3 January 5, 2023

7:30 - 8:30 am

Breakfast (provided)

Foyer of ballroom
SESSION 4  - Chair Jonathan Javitch
8:30 – 9:10 am
Seeing scents: towards a structural understanding of olfaction

Christian Billesboelle
UCSF

9:10 - 9:50 am
G protein-coupled versus arrestin-coupled receptors: exploiting mechanistic differences for therapeutic benefit.

Evi Kostenis
University of Bonn

9:50 - 10:30 am
GPCRs as guidance receptors for immune cells.

Jason Cyster
UCSF

10:30 - 11:10 am
Fantastic adhesion GPCRs and how to target them

Ines Liebscher
Leipzig University

11:10 - 11:30 am
Break
11:30 - 11:50 am
Short Talk - A novel orphan GPCR screening platform for the identification of small molecule pharmacochaperones targeting brain-specific oGPCRs

Daniela Dengler
Sanford Burnham Prebys Medical Discovery Institute

11:50 - 12:10 pm
Short Talk - High-throughput Genetic Platforms to Study GPCR Biology

Matthew Howard
UCSF

12:10 - 3:00 pm
Lunch (on your own) and poster viewing
SESSION 5 - Chair Brian Kobilka
3:00 - 3:40 pm
Subcellular location and movement of GPCR-mediated signaling

Mark von Zastrow
UCSF

3:40 - 4:20 pm
Dynamics of class-B GPCR

Osamu Nureki
University of Tokyo

4:20 - 4:40 pm
Short Talk - Probing autoinhibition and tethered agonism across the full family of Adhesion GPCRs.

Andrew Dates
Harvard

4:40 -5:00 pm
Short Talk - PI(4,5)P2-stimulated positive feedback drives Wnt/beta-catenin signaling

Jacob Mahoney
Stanford Univ

5:00 - 5:20 pm
Short Talk - Mapping the diversity in spatiotemporal regulation of G protein-coupled receptors

Ruth Huettenhain
UCSF

6:00 - 8:00 pm
Dinner (provided)
8:00 - 10:00 pm
INTERACTIVE SESSION 2

Sebastian Granier
University of Montpellier, France

Day 4 January 6, 2023

7:30 - 8:30 am

Breakfast (provided)

Foyer of ballroom
SESSION 6 - Chair Jurgen Wess
8:30 - 9:10 am
Structural mass spectrometry to probe chemokine receptors interactions and dynamics

Cherine Bechara
University of Montpellier, France

9:10 - 9:50 am
Neuropeptides controlling mosquito behavior

Laura Duvall
Columbia University

9:50 - 10:30 am
Structural dynamics of Class C GPCRs using single molecule FRET techniques

Josh Levitz
Cornell University

10:30 - 11:10 am
GPCR Drug Discovery from the Bench to the Patient: Paltusotine

Scott Struthers & Stephen Betz
Crinetics

11:10 - 11:30 am
Break
11:30 - 11:50 am
Structure driven drug discovery and design: case study of a Family A GPCR

Bingfa Sun
ConfometRx, Inc

11:50 - 12:10 pm
Short Talk - Monitoring neuropeptide release with genetically encoded biosensors.

Yihan Jin
UC Davis

12:10 - 3:00 pm
Lunch (on your own) and poster viewing
SESSION 7 - Chair Osamu Nureki
3:00 - 3:40 pm
The open conformation of Gas: implications to signaling and disease

Roger Sunahara
UC San Diego

3:40 - 4:20 pm
Function-related dynamics of GPCRs by NMR

Ichio Shimada
BDR Riken, Japan

4:20 - 5:10 pm
Structure and activation mechanism of the RXFP1 relaxin receptor

Andrew Kruse
Harvard University

5:10 - 5:20 pm
Closing Remarks
5:20 - 6:00 pm
Poster take-down
6:00 - 9:00 pm

BANQUET DINNER